Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin

Akitsu Ogawa; Chikako Murakami; Shinji Kamisuki; Isoko Kuriyama; Hiromi Yoshida; Fumio Sugawara; Yoshiyuki Mizushina

doi:10.1016/j.bmcl.2004.04.050

Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3539-43. doi: 10.1016/j.bmcl.2004.04.050.

Authors

Akitsu Ogawa¹, Chikako Murakami, Shinji Kamisuki, Isoko Kuriyama, Hiromi Yoshida, Fumio Sugawara, Yoshiyuki Mizushina

Affiliation

¹ Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan.

PMID: 15177469
DOI: 10.1016/j.bmcl.2004.04.050

Abstract

A new isochroman derivative named pseudodeflectusin was isolated from a culture broth of Aspergillus pseudodeflectus. The structure was determined by spectroscopic means as 9-hydroxy-7-methyl-2-(methylethylidine)-furano[3,2-H]isochroman-3-one. This compound exhibited cytotoxicity for several human cancer cell lines from the stomach (NUGC-3), cervix (HeLa-S3), and peripheral blood (HL-60), but did not affect those from the lung (A549) or colon (DLD-1). The LD50 value of this compound for HL-60 cells was 39 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Aspergillus / chemistry*
Chromans / chemistry
Chromans / isolation & purification*
Chromans / pharmacology
Eukaryota / microbiology*
Female
Glutathione / metabolism
HL-60 Cells
HeLa Cells
Humans
Male
Molecular Structure
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Chromans
pseudodeflectusin
Glutathione